Tumor Necrosis Factor Alpha ELISA Detection
Tumor Necrosis Factor Alpha (TNF-α) is a cytokine, a type of signaling molecule involved in cell-to-cell communication in the immune system. It plays a crucial role in inflammation and immune responses, particularly during acute and chronic inflammatory processes.
Some key functions of TNF-α include:
Inducing inflammation: TNF-α helps initiate the inflammatory response by attracting immune cells to the site of injury or infection. It promotes the release of other inflammatory cytokines, such as interleukins.
Apoptosis: TNF-α can trigger programmed cell death (apoptosis) in certain cell types. This function is essential for eliminating infected or damaged cells to prevent the spread of infection or tissue damage.
Upregulating adhesion molecules: It increases the expression of adhesion molecules on endothelial cells, which facilitate the binding and migration of immune cells to the site of inflammation.
Fever induction: TNF-α is involved in the regulation of body temperature and can cause fever as part of the body’s defense mechanism against infections.
Therapeutic use of TNF-α inhibitors:
While TNF-α is essential for the immune response, excessive TNF-α production is associated with several inflammatory and autoimmune conditions, such as rheumatoid arthritis, psoriasis, Crohn’s disease, and ankylosing spondylitis. To treat these conditions, researchers have developed TNF-α inhibitors, which are medications that can block the activity of TNF-α.
Some commonly used TNF-α inhibitors include:
- Infliximab (Remicade)
- Adalimumab (Humira)
- Etanercept (Enbrel)
- Certolizumab pegol (Cimzia)
- Golimumab (Simponi)
The provided microtiter plate comes pre-coated with an antibody specific to Tumor Necrosis Factor Alpha (TNFa) . To perform the assay, standards or samples are added to designated wells on the microtiter plate. Subsequently, a biotin-conjugated antibody specific to Tumor Necrosis Factor Alpha (TNFa) is introduced.
Size : 96 Test
You may also need :
- AffiELISA® Pig TNFa Kit: Ultra-Sensitive Tumor Necrosis Factor Alpha ELISA Detection
- AffiELISA® Rat TNFa Kit: High Sensitivity Tumor Necrosis Factor Alpha ELISA Detection
- AffiELISA® Simian TNFa Kit: High Sensitivity Tumor Necrosis Factor Alpha ELISA Detection
- AffiELISA® Mouse TNFa Kit: High Sensitivity Tumor Necrosis Factor Alpha ELISA Detection