Marburg Hemorrhagic Fever developed with recombinant proteins

 Marburg virus detection 

The origen of marburg virus :

The Marburg virus is named after the city of Marburg, Germany, where the first recognized outbreak of the virus occurred in 1967. The virus was identified when laboratory workers in Marburg and Frankfurt became infected after handling African green monkeys, which had been imported from Uganda for research purposes. The outbreak resulted in several cases of severe hemorrhagic fever with a high mortality rate.


Micrograph of the Marburg viruses

Marburg and Ebola Virus Infections : 

The Marburg virus belongs to the family Filoviridae, which also includes the Ebola virus. Both viruses are highly virulent and can cause severe and often fatal illnesses in humans and other primates. The natural reservoir, or the animal species in which the virus normally resides, is believed to be fruit bats of the Pteropodidae family.

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How can detect Marburg virus ?

The Marburg virus can be detected through various laboratory methods, particularly during the acute phase of the infection when the virus is present in the bloodstream. Early detection is crucial for timely treatment and implementing infection control measures to prevent further transmission.

PCR (Polymerase Chain Reaction): This is one of the most common methods for detecting the genetic material (RNA) of the Marburg virus. It allows for the specific amplification of viral RNA, making it easier to identify the virus even in low concentrations.

Antigen Capture Assays: These tests detect specific viral proteins in blood or other bodily fluids. They can be helpful in diagnosing acute infections.

Virus Isolation: The Marburg virus can be isolated and grown in specialized laboratories. However, this method is highly risky and is usually performed in high-containment facilities.

Serological Tests: These tests detect antibodies produced by the immune system in response to the Marburg virus. They are useful in identifying past infections or for serosurveys to determine the extent of outbreaks.

Human Anti-Marburg (Angola) glycoprotein:





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